The efficacy of both azithromycin and doxycycline was high for the treatment of urogenital chlamydia infection among adolescents in youth correctional facilities, with the noninferiority of azithromycin to doxycycline not established. This according to a study of 567 participants where 284 were randomly assigned to receive azithromycin, and 283 were randomly assigned to receive doxycycline. Researchers found:
• There were no treatment failures in the doxycycline group.
• Treatment failure occurred in 5 participants (3.2%) in the azithromycin group.
• The efficacy of both types of treatment was high (97% vs 100%) with the noninferiority of azithromycin not established in the study setting.
Citation: Geisler WM, Uniyal A, Lee JY. Azithromycin versus doxycycline for urogenital chlamydia trachomatis infection. N Engl J Med 2015;373:2512-21. doi: 10.1056/NEJMoa1502599.
1. Centers for Disease Control and Prevention Web site. STD treatment guidelines 2015 at http://www.cdc.gov/std/treatment/default.htm.
This Week's Must Reads
Must Reads in Sexual Health
Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force
Treating Urogenital Chlamydia Infection, Is doxycycline superior to azithromycin?
FDA Approves Sexual Desire Disorder Drug, Flibanserin (Addyi) approved to treat premenopausal women
Obesity and Hormonal Contraceptives, Is there increased risk of unintended pregnancy?