The efficacy of both azithromycin and doxycycline was high for the treatment of urogenital chlamydia infection among adolescents in youth correctional facilities, with the noninferiority of azithromycin to doxycycline not established. This according to a study of 567 participants where 284 were randomly assigned to receive azithromycin, and 283 were randomly assigned to receive doxycycline. Researchers found:
• There were no treatment failures in the doxycycline group.
• Treatment failure occurred in 5 participants (3.2%) in the azithromycin group.
• The efficacy of both types of treatment was high (97% vs 100%) with the noninferiority of azithromycin not established in the study setting.
Citation: Geisler WM, Uniyal A, Lee JY. Azithromycin versus doxycycline for urogenital chlamydia trachomatis infection. N Engl J Med 2015;373:2512-21. doi: 10.1056/NEJMoa1502599.
1. Centers for Disease Control and Prevention Web site. STD treatment guidelines 2015 at http://www.cdc.gov/std/treatment/default.htm.
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