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Prescribed Opioids & Risk of CAP in Patients with HIV

JAMA Intern Med; 2019 Jan 7; Edelman, et al

Among persons with and without HIV, prescribed opioids, especially higher-dose and immunosuppressive opioids, are associated with increased community-acquired pneumonia (CAP) risk, a recent study found. The nested case-control study included 4,246 cases and 21,146 controls (n=25,392) participants living with and without HIV who received care in Veterans Health Administration (VA) medical centers across the US. The primary outcome was CAP requiring hospitalization. Researchers found:

  • Prescribed opioids were independently associated with CAP in those living with and without HIV.
  • The risk for CAP increased with higher opioid doses and opioids with known immunosuppressive properties.
  • In stratified analyses, CAP risk was consistently greater among people living with HIV with current prescribed opioids.

Citation:

Edelman EJ, Gordon KS, Crothers K, et al. Association of prescribed opioids with increased risk of community-acquired pneumonia among patients with and without HIV. [Published online ahead of print January 7, 2019]. JAMA Intern Med. doi:10.1001/jamainternmed.2018.6101.

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