Among persons with and without HIV, prescribed opioids, especially higher-dose and immunosuppressive opioids, are associated with increased community-acquired pneumonia (CAP) risk, a recent study found. The nested case-control study included 4,246 cases and 21,146 controls (n=25,392) participants living with and without HIV who received care in Veterans Health Administration (VA) medical centers across the US. The primary outcome was CAP requiring hospitalization. Researchers found:
- Prescribed opioids were independently associated with CAP in those living with and without HIV.
- The risk for CAP increased with higher opioid doses and opioids with known immunosuppressive properties.
- In stratified analyses, CAP risk was consistently greater among people living with HIV with current prescribed opioids.
Edelman EJ, Gordon KS, Crothers K, et al. Association of prescribed opioids with increased risk of community-acquired pneumonia among patients with and without HIV. [Published online ahead of print January 7, 2019]. JAMA Intern Med. doi:10.1001/jamainternmed.2018.6101.
This Week's Must Reads
Androgen Deprivation Therapy & Risk of Depression, Cancer; ePub 2019 Feb 12; Deka, Rose, et al
QOL in Patients with Low-Risk PC Treated with HRT, JAMA Oncol; ePub 2019 Feb 14; Bruner, et al
Hospital Competition & Prostate Cancer Outcomes, Cancer; ePub 2019 Feb 1; Aggarwal, et al
Insurance Status & Stage of Prostate Ca Diagnosis, Cancer Epidemiol; 2019 Apr; Ramirez, Morano, et al
Agent Orange Exposure & Prostate Ca Outcomes, J Urol; ePub 2019 Jan 8; Etheridge, et al
Must Reads in Pain
Opioid-Related Mortality in US by Opioid Type, JAMA Netw Open; 2019 Feb 22; Kiang, et al
Disparities in the Prescription of Opioids, JAMA Intern Med; ePub 2019 Feb 11; Friedman, et al
Trends in Pain Prevalence in US Adults, J Pain; ePub 2019 Jan 15; Nahin, et al
Prescribed Opioids & Risk of CAP in Patients with HIV, JAMA Intern Med; 2019 Jan 7; Edelman, et al
Opioid-Involved Overdose Deaths in the US, MMWR; 2019 Jan 4; Scholl, Seth, et al