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Cancer Incidence Rates in HIV-Infected Adults

Ann Intern Med; ePub 2018 May 8; Shiels, et al

The cancer burden among people living with HIV (PLWH) in the US is projected to shift over the next 12 years, with prostate and lung cancer expected to emerge as the most common types by 2030. Researchers projected cancer rates and burden among HIV-infected adults in the US by age during 2006 to 2030 for AIDS-defining cancer (ADC)—Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer—and certain type of non-AIDS-defining cancer (NADC). All other cancer types were combined. They found:

  • The proportion of adult PLWH in the US aged ≥65 years is projected to increase from 8.5% in 2010 to 21.4% in 2030.
  • Age-specific rates are projected to decrease through 2030 across age groups for Kaposi sarcoma, non-Hodgkin lymphoma, cervical cancer, lung cancer, Hodgkin lymphoma, and other cancer types combined, and among those aged ≥65 years for colon cancer.
  • The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030.
  • Prostate and lung cancer are projected to be the most common cancer types in this study population in 2030.


Shiels MS, Islam JY, Rosenberg PS, Hall HI, Jacobson E, Engels EA. Projected cancer incidence rates and burden of incident cancer cases in HIV-infected adults in the United States through 2030. [Published online ahead of print May 8, 2018]. Ann Intern Med. doi:10.7326/M17-2499.