Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cancer Incidence Rates in HIV-Infected Adults

Ann Intern Med; ePub 2018 May 8; Shiels, et al

The cancer burden among people living with HIV (PLWH) in the US is projected to shift over the next 12 years, with prostate and lung cancer expected to emerge as the most common types by 2030. Researchers projected cancer rates and burden among HIV-infected adults in the US by age during 2006 to 2030 for AIDS-defining cancer (ADC)—Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer—and certain type of non-AIDS-defining cancer (NADC). All other cancer types were combined. They found:

  • The proportion of adult PLWH in the US aged ≥65 years is projected to increase from 8.5% in 2010 to 21.4% in 2030.
  • Age-specific rates are projected to decrease through 2030 across age groups for Kaposi sarcoma, non-Hodgkin lymphoma, cervical cancer, lung cancer, Hodgkin lymphoma, and other cancer types combined, and among those aged ≥65 years for colon cancer.
  • The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030.
  • Prostate and lung cancer are projected to be the most common cancer types in this study population in 2030.


Shiels MS, Islam JY, Rosenberg PS, Hall HI, Jacobson E, Engels EA. Projected cancer incidence rates and burden of incident cancer cases in HIV-infected adults in the United States through 2030. [Published online ahead of print May 8, 2018]. Ann Intern Med. doi:10.7326/M17-2499.

This Week's Must Reads

ACIP Updates Adult Immunization Schedule, Ann Intern Med; 2019 Feb 5; Kim, Hunter, et al

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

Prevention of Prescription Opioid Misuse in the US, JAMA Netw Open; 2019 Feb 1; Chen, et al

E-cigarettes & Risk of Tobacco Cigarette Initiation, JAMA Netw Open; 2019 Feb 1; Berry, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al

Must Reads in Oncology

Do Vitamin D Supplements Prevent Cancer, CVD?, N Engl J Med; 2019 Jan 3; Manson, Cook, et al

Nonadherence to Cancer Screenings & Related Mortality, JAMA Intern Med; ePub 2018 Dec 28; Pierre-Victor, et al

Does Vitamin D Reduce Cancer & CVD Risk?, N Engl J Med; ePub 2018 Nov 10; Manson, et al

Interventions to Increase CRC Screening Rates, JAMA Intern Med; ePub 2018 Oct 15; Dougherty, et al

Smoking & Lung Cancer Mortality in the US to 2065, Ann Intern Med; ePub 2018 Oct 9; Jeon, et al