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Treating Patients with HCV/HIV Coinfection

Hepatology; 2018 Mar; Sikavi, Chen, et al

Patients with hepatitis C virus and human immunodeficiency virus coinfection (HCV/HIV) can be successfully treated with direct-acting antivirals (DAAs), which have resulted in similarly high rates of sustained virologic response (SVR) for HCV infection in those with and without HIV infection. This according to a recent review of studies for this “special population” of patients between January 2004 and July 2017. Among the findings:

  • SVR rates for those with HCV/HIV coinfection treated with interferon-based therapies were substantially lower than SVR rates of HCV-monoinfected individuals.
  • DAA agents has resulted in similar SVR rates between monoinfected and coinfected individuals, with SVR >93%.
  • Clinicians should be aware of negative predictors of SVR and barriers to treatment that may be more common in coinfected individuals.

Citation:

Sikavi, C, Chen PH, Lee AD, Saab EG, Choi G, Saab S. Hepatitis C and human immunodeficiency virus coinfection in the era of direct-acting antiviral agents: No longer a difficult-to-treat population. Hepatology. 2018;67(3):847–857. doi:10.1002/hep.29642.

This Week's Must Reads

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al

Must Reads in Hepatitis

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al