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Treating Patients with HCV/HIV Coinfection

Hepatology; 2018 Mar; Sikavi, Chen, et al

Patients with hepatitis C virus and human immunodeficiency virus coinfection (HCV/HIV) can be successfully treated with direct-acting antivirals (DAAs), which have resulted in similarly high rates of sustained virologic response (SVR) for HCV infection in those with and without HIV infection. This according to a recent review of studies for this “special population” of patients between January 2004 and July 2017. Among the findings:

  • SVR rates for those with HCV/HIV coinfection treated with interferon-based therapies were substantially lower than SVR rates of HCV-monoinfected individuals.
  • DAA agents has resulted in similar SVR rates between monoinfected and coinfected individuals, with SVR >93%.
  • Clinicians should be aware of negative predictors of SVR and barriers to treatment that may be more common in coinfected individuals.

Citation:

Sikavi, C, Chen PH, Lee AD, Saab EG, Choi G, Saab S. Hepatitis C and human immunodeficiency virus coinfection in the era of direct-acting antiviral agents: No longer a difficult-to-treat population. Hepatology. 2018;67(3):847–857. doi:10.1002/hep.29642.

This Week's Must Reads

How to Improve HCV Treatment Access in the US, J Public Health Manag Pract; ePub 2018 Jun 20; Kapadia, et al

Hepatitis B and C & Risk of Liver Cancer, Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Barriers in the HCV Cascade of Care, PLoS One; ePub 2018 Jun 18; Zuckerman, et al

HCV Testing & Treatment Among PWID, Subst Use Misuse; ePub 2018 Jun 22; Boucher, et al

HCC Development After Viral Clearance in CHC , J Digest Dis; ePub 2018 Jun 11; Tong, et al

Must Reads in Hepatitis

How to Improve HCV Treatment Access in the US, J Public Health Manag Pract; ePub 2018 Jun 20; Kapadia, et al

Hepatitis B and C & Risk of Liver Cancer, Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Barriers in the HCV Cascade of Care, PLoS One; ePub 2018 Jun 18; Zuckerman, et al

HCV Testing & Treatment Among PWID, Subst Use Misuse; ePub 2018 Jun 22; Boucher, et al

HCC Development After Viral Clearance in CHC , J Digest Dis; ePub 2018 Jun 11; Tong, et al