Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

SVR & Risk of T2D Among Patients with HCV

J Viral Hepat; ePub 2018 Feb 25; Li, Zhang, et al

Among a large US cohort of patients treated for hepatitis C virus (HCV), patients who achieved sustained virological response (SVR) demonstrated a substantially lower risk for development of type 2 diabetes mellitus (T2D) than patients with treatment failure. This according to a study that examined how response to HCV treatment impacts risk of subsequent T2D. Among HCV patients without a history of T2D or hepatitis B, researchers investigated incidence of T2D from 12 weeks post-HCV-treatment through December 2015. They found:

  • Among 5,127 patients with an average follow-up of 3.7 years, T2D incidence was significantly lower among patients who achieved SVR than among patients with treatment failure (6.2% vs 21.7%).
  • Risk of T2D was higher among African American and Asian American patients vs white patients (adjusted hazard ratio [aHR], 1.82 and 1.75, respectively).
  • Patients with body mass index (BMI) ≥30 and 25-20 demonstrated higher risk than those with BMI <25.
  • Cirrhosis at baseline was also a risk factor.


Li J, Zhang T, Gordon SC, et al. Impact of sustained virological response on risk of type 2 diabetes among hepatitis C patients in the US. [Published online ahead of print February 25, 2018]. J Viral Hepat. doi:10.1111/jvh.12887.

This Week's Must Reads

Lifestyle Behavioral Risk Factors for T2D, Diabetes Care; ePub 2018 Mar 2; Siegel, et al

Association of BMI with Lifetime Risk of CVD, JAMA Cardiol; ePub 2018 Feb 28; Khan, et al

Collaborative Care vs Usual Care in Heart Failure, JAMA Intern Med; ePub 2018 Feb 26; Bekelman, et al

Efficacy of CBT vs Education for Chronic Pain, Ann Intern Med; ePub 2018 Feb 27; Thorn, et al

Hypertension & Antihypertensive Medication Use, MMWR; 2018 Feb 23; Fang, Gillespie, et al

Must Reads in Hepatitis

Electronic Reminder Systems for HCV Screening, J Viral Hepat; ePub 2018 Feb 25; MacLean, et al

Universal HCV Screening During Pregnancy, Open Forum Infect Dis; ePub 2018 Feb 17; Boudova, et al

SVR & Risk of T2D Among Patients with HCV, J Viral Hepat; ePub 2018 Feb 25; Li, Zhang, et al

Chronic HCV Prognosis in TE-based Liver Stiffness, J Viral Hepat; ePub 2018 Jan 24; Erman, et al

Measuring HCV Intervention Success, J Viral Hepat; ePub 2018 Feb 27; Harris, et al