Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Risk of HCV Among Vulnerable Populations

J Viral Hepat; ePub 2018 May 31; Aisyah, et al

Effective models need to be developed to ensure case identification in vulnerable settings and among vulnerable populations that can lead to effective treatment and efficient hepatitis C virus (HCV) prevention, a new study suggests. The cross-sectional study between May 2011 and June 2013 sought to estimate the prevalence of HCV in vulnerable populations that included homelessness, people who inject drugs (PWID), and prisoners. A questionnaire was administered and blood sample were tested for HCV. Among the details:

  • 491 individuals who were homeless (40.7%), 205 drug users (17%), and 511 prisoners (42.3%) were recruited.
  • Overall, one-quarter of those recruited in drug treatment services, 13% of those from homeless residential sites, and 4% of prisoners were anti-HCV positive.
  • 56.6% of HCV-infected participants identified had a history of all 3 risk factors, 27.3% had 2 overlapping risk factors, and 15.4% had 1 risk factor.


Aisyah DN, Shallcross L, Hayward A, et al. Hepatitis C among vulnerable populations: A seroprevalence study of homeless, people who inject drugs, and prisoners in London. [Published online ahead of print May 31, 2018]. J Viral Hepat. doi:10.1111/jvh.12936.

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