Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hepatitis B and C & Risk of Liver Cancer

Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Hepatocellular carcinoma (HCC) and HIV represent substantial risk to survival for both hepatitis C virus (HBV) and hepatitis C virus (HCV)-infected individuals, while those infected with HCV have higher odds of HCC diagnosis. This according to a recent study that identified all individuals reported with HBV or HBC in New York City from 2001-2012 and measured their risk of developing HCC and their risk of death by HCC and HIV status. Among the details:

  • 120,952 and 127,933 individuals were diagnosed with HBV or HCV, respectively.
  • HCV-infected individuals had 17% higher odds of HCC diagnosis than those infected with HBV and 3.2 times higher odds of HIV coinfection.
  • Those with HCV were twice as likely to die during the study period (adjusted HR: 2.04).
  • The risk of death increased for those with HIV or HCC and was highest for those with both conditions.


Moore MS, Bocour A, Tran OC, et al. Effect of hepatocellular carcinoma on mortality among individuals with hepatitis B or hepatitis C infection in New York City, 2001-2012. [Published online ahead of print June 16, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy144.

This Week's Must Reads

Global Burden of CVD in People Living with HIV, Circulation; ePub 2018 Jul 2; Shah, et al

Penicillin Allergy & Risk of MRSA and C. difficle, BMJ; ePub 2018 Jun 27; Blumenthal, et al

Does Sleep Debt Decrease with Age? , Sleep Health; ePub 2018 Jun 28; Fox, et al

Firearm Injuries in Children & Adolescents, Pediatrics; ePub 2018 Jul 2; Herrin, et al

Effects of Pulse Pressure & BP Tx Intensity on AEs, Am J Med; ePub 2018 Jun 22; Krishnaswami, et al

Must Reads in Hepatitis

How to Improve HCV Treatment Access in the US, J Public Health Manag Pract; ePub 2018 Jun 20; Kapadia, et al

Hepatitis B and C & Risk of Liver Cancer, Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Barriers in the HCV Cascade of Care, PLoS One; ePub 2018 Jun 18; Zuckerman, et al

HCV Testing & Treatment Among PWID, Subst Use Misuse; ePub 2018 Jun 22; Boucher, et al

HCC Development After Viral Clearance in CHC , J Digest Dis; ePub 2018 Jun 11; Tong, et al