Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hepatitis B and C & Risk of Liver Cancer

Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Hepatocellular carcinoma (HCC) and HIV represent substantial risk to survival for both hepatitis C virus (HBV) and hepatitis C virus (HCV)-infected individuals, while those infected with HCV have higher odds of HCC diagnosis. This according to a recent study that identified all individuals reported with HBV or HBC in New York City from 2001-2012 and measured their risk of developing HCC and their risk of death by HCC and HIV status. Among the details:

  • 120,952 and 127,933 individuals were diagnosed with HBV or HCV, respectively.
  • HCV-infected individuals had 17% higher odds of HCC diagnosis than those infected with HBV and 3.2 times higher odds of HIV coinfection.
  • Those with HCV were twice as likely to die during the study period (adjusted HR: 2.04).
  • The risk of death increased for those with HIV or HCC and was highest for those with both conditions.


Moore MS, Bocour A, Tran OC, et al. Effect of hepatocellular carcinoma on mortality among individuals with hepatitis B or hepatitis C infection in New York City, 2001-2012. [Published online ahead of print June 16, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy144.

This Week's Must Reads

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al

Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al

Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Must Reads in Hepatitis

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al