Clinical Edge

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Hepatitis B and C & Risk of Liver Cancer

Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Hepatocellular carcinoma (HCC) and HIV represent substantial risk to survival for both hepatitis C virus (HBV) and hepatitis C virus (HCV)-infected individuals, while those infected with HCV have higher odds of HCC diagnosis. This according to a recent study that identified all individuals reported with HBV or HBC in New York City from 2001-2012 and measured their risk of developing HCC and their risk of death by HCC and HIV status. Among the details:

  • 120,952 and 127,933 individuals were diagnosed with HBV or HCV, respectively.
  • HCV-infected individuals had 17% higher odds of HCC diagnosis than those infected with HBV and 3.2 times higher odds of HIV coinfection.
  • Those with HCV were twice as likely to die during the study period (adjusted HR: 2.04).
  • The risk of death increased for those with HIV or HCC and was highest for those with both conditions.


Moore MS, Bocour A, Tran OC, et al. Effect of hepatocellular carcinoma on mortality among individuals with hepatitis B or hepatitis C infection in New York City, 2001-2012. [Published online ahead of print June 16, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy144.