Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hepatitis B and C & Risk of Liver Cancer

Open Forum Infect Dis; ePub 2018 Jun 16; Moore, et al

Hepatocellular carcinoma (HCC) and HIV represent substantial risk to survival for both hepatitis C virus (HBV) and hepatitis C virus (HCV)-infected individuals, while those infected with HCV have higher odds of HCC diagnosis. This according to a recent study that identified all individuals reported with HBV or HBC in New York City from 2001-2012 and measured their risk of developing HCC and their risk of death by HCC and HIV status. Among the details:

  • 120,952 and 127,933 individuals were diagnosed with HBV or HCV, respectively.
  • HCV-infected individuals had 17% higher odds of HCC diagnosis than those infected with HBV and 3.2 times higher odds of HIV coinfection.
  • Those with HCV were twice as likely to die during the study period (adjusted HR: 2.04).
  • The risk of death increased for those with HIV or HCC and was highest for those with both conditions.

Citation:

Moore MS, Bocour A, Tran OC, et al. Effect of hepatocellular carcinoma on mortality among individuals with hepatitis B or hepatitis C infection in New York City, 2001-2012. [Published online ahead of print June 16, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy144.

This Week's Must Reads

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al

Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al

Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Must Reads in Hepatitis

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al