Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

HCV Testing & Treatment Among PWID

Subst Use Misuse; ePub 2018 Jun 22; Boucher, et al

Increased access to hepatitis C virus (HCV) treatment for people who inject drugs (PWID) is urgently needed, according to a recent study that examined HCV testing, status, and treatment among marginalized people who use drugs in an inner city setting. Researchers analyzed data from a cross-sectional, peer-administered survey of PWID from 2012 to 2013. They found:

  • Among 663 participants, 562 (84.8%) reported testing for HCV and 258 (45.9%) reported HCV-positive status.
  • In multivariable analysis, HCV-positive status was associated with female gender, advancing age, receiving disability payments, injecting drugs, ever injecting with a used needle, and ever having taken methadone.
  • Of 196 (76%) HCV-positive participants, 196 (76%) were engaged in primary care but only 23 (8.9%) had received HCV therapy.


Boucher LM, Bayoumi AM, Mark AE, et al. Hepatitis C testing, status and treatment among marginalized people who use drugs in an inner city setting: An observational cohort study. [Published online ahead of print June 22, 2018]. Subst Use Misuse. doi:10.1080/10826084.2018.1485699.

This Week's Must Reads

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al

Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al

Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Must Reads in Hepatitis

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al