Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

HCV Testing Recommendations in High-Income Countries

World J Hepatol; 2018 Oct 27; Irwin, Ward, et al

Similarities in testing for hepatitis C virus (HCV) infection exist between the HCV Guidance Panel’s (US) guidance with those of recommendations from very high Human Development Index (HDI) countries. Researchers investigated HCV testing recommendations from the US and other high-income countries. A comprehensive search for current HCV testing recommendations from the top quartile of the United Nations HDI countries was performed and reviewed from May 1, 2014 to October 30, 2014 and re-reviewed from April 1, 2017 to October 2, 2017. Among the findings:

  • Of the 51 countries identified, 16 had HCV testing recommendations from a government body or recommendations issued collaboratively between a government and a medical organization.
  • Of these, 15 countries had HCV testing recommendations that were primarily risk-based and highlight behaviors, exposures, and conditions that are associated with HCV transmission in that region.
  • The HCV Guidance Panel (US) also incorporates recommendations for a 1-time test for individuals born between 1945-1965 without prior ascertainment of risk into their guidance.
  • 6 other countries either have an age-based testing recommendation or recommend 1-time testing for all adults independent of risk factors typical of the region.


Irwin R, Ward K, Agee T, et al. Comparison of hepatitis C virus testing recommendations in high-income countries. World J Hepatol. 2018;10(10):743-751. doi:10.4254/wjh.v10.i10.743.

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