Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

HCV Infection & All-Cause Mortality in HIV

Clin Infect Dis; ePub 2018 Oct 12; Breskin, et al

Hepatitis C virus (HCV) coinfection remains a significant risk factor for mortality among people living with human immunodeficiency virus (PLwH) after initiating antiretroviral therapy (ART), a recent study found. Researchers analyzed data from the Women’s Interagency HIV Study and the Multicenter AIDS Cohort Study. Participants included those who had prevalent HIV or seroconverted during follow-up, and all were antiretroviral-naïve and acquired immunodeficiency syndrome (AIDS)-free prior to their first visits after October 1, 1994. Follow-up lasted 10 years. Among the findings:

  • There were 3,056 eligible participants (58% female, 18% had HCV).
  • The estimated 10-year all-cause mortality risk in which no PLwH had HCV was 10.4%.
  • The 10-year mortality risk difference for HCV infection was 4.3% (risk ratio [RR] 1.4).
  • The risk difference for direct-acting antiviral (DAA) treatment was ‒3.8% (RR 0.8).


Breskin A, Westreich D, Cole SR, et al. The effects of hepatitis C infection and treatment on all-cause mortality among people living with human immunodeficiency virus. [Published online ahead of print October 12, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy588.

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HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al

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Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al