Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

HCV Incidence From Injection Paraphernalia

J Infect Dis; 2018 Jan; Heimer, Binka, et al

Sharing paraphernalia does not directly result in hepatitis C virus (HCV) transmission but instead is a surrogate for transmissions resulting from sharing drugs, a recent study found. In experiments designed to replicate real-world injection practices when drugs are shared, the residual contents of HCV-contaminated syringes with detachable or fixed needles were passed through the “cookers” and filters used by people who inject drugs (PWID) in preparing drugs for injection and then introduced into a second syringe. All items were tested for the presence of infectious HCV using a chimeric HCV with a luciferase gene. Researchers found:

  • HCV could not be recovered from cookers regardless of input syringe type or cooker design.
  • Recovery was higher when comparing detachable needles to fixed needles for residue in input syringes, filters, and receptive syringes.


Heimer R, Binka M, Koester S, et al. Recovery of infectious hepatitis C virus from injection paraphernalia: Implications for prevention programs serving people who inject drugs. J Infect Dis. 2018;217(3):466-473. doi:10.1093/infdis/jix427.

This Week's Must Reads

Do Vitamin D Supplements Prevent Cancer, CVD?, N Engl J Med; 2019 Jan 3; Manson, Cook, et al

Nonadherence to Cancer Screenings & Related Mortality, JAMA Intern Med; ePub 2018 Dec 28; Pierre-Victor, et al

Alcohol Consumption After Development of HF, JAMA Netw Open; ePub 2018 Dec 28; Sadhu, et al

Opioid-Involved Overdose Deaths in the US, MMWR; 2019 Jan 4; Scholl, Seth, et al

Assessing the Diet Quality of US Children, Am J Clin Nutrit; ePub 2018 Dec 29; Thomson, et al

Must Reads in Hepatitis

Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al

HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al

HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al

Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al

Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al