Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Gut Dysbiosis Associated with HCV Infection?

Clin Infect Dis; ePub 2018 May 1; Inoue, et al

Hepatitis C virus (HCV) infection is associated with gut dysbiosis, even in patients with mild liver disease, a recent study found. Fecal samples from 166 chronic hepatitis C (CHC) patients were compared with those from 23 healthy individuals. CHC patients were diagnosed with persistently normal serum alanine aminotransferase without evidence of liver cirrhosis (LC) (PNALT, n=18), chronic hepatitis (CH, n=84), LC (n=40), and hepatocellular carcinoma in LC (n=24). Researchers found:

  • Bacterial diversity was lower in those with HCV infection, with a decrease in the order Clostridiales and an increased in Streptococcus and Lactobacillus.
  • Microbiota dysbiosis already appeared in the PNALT stage with the transient increase in Bacteroides and Enterobacteriaceae.
  • Overgrowth of ciridans streptococci can account for hyperammonemia in CH and LC.


Inoue T, Nakayama J, Moriya K, et al. Gut dysbiosis associated with hepatitis C virus infection. [Published online ahead of print May 1, 2018]. Clin Infect Dis. doi.10.1093/cid/ciy205.

This Week's Must Reads

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Outpatient Care for Adults With Primary Care, JAMA Intern Med; ePub 2019 Jan 28; Levine, et al

Antibiotic Therapy in Patients with Asthma, JAMA Intern Med; ePub 2019 Jan 28; Stefan, et al

Outpatient Benzodiazepine Prescribing in US, JAMA Netw Open; 2019 Jan 25; Agarwal, et al

Reduction of Readmissions Through Primary Care, JAMA Netw Open; 2019 Jan 25; Wiest, et al

Must Reads in Hepatitis

Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al

HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al

HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al

Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al

Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al