In patients with chronic hepatitis C (CHC) without cirrhosis, short-duration treatment with glecaprevir/pibrentasvir (G/P) resulted in stable renal function and improvements in cardiovascular (CV) and metabolic extrahepatic manifestation (EHM) markers, especially in those with severe EHMs at baseline. This according to a post-hoc analysis of 2 phase 3 clinical trials in patients without cirrhosis treated with G/P for 8 weeks. In addition, 1 phase 3 trial was carried out to explore the effects of treatment on renal EHMs in patients with advanced renal impairment at baseline. Researchers included all CHC patients treated with G/P for 8 or 12 weeks enrolled across 5, phase 3 trials as a sensitivity analysis. They found:
- G/P treatment for 8 weeks resulted in statistically significant declines in triglycerides (‒28.6 mg/dL) and glucose (‒11.2 mg/dL), with no statistically significant decline in estimated glomerular filtration rate (eGFR).
- Biomarker improvements were greatest among patients with elevated triglycerides and elevated glucose at baseline.
- Similar effects were observed across all patients treated with G/P for 8 or 12 weeks.
Tran TT, Mehta D, Mensa F, Park C, Bao Y, Sanchez Gonzalez Y. Pan-genotypic hepatitis C treatment with glecaprevir and pibrentasvir for 8 weeks resulted in improved cardiovascular and metabolic outcomes and stable renal function: A post-hoc analysis of phase 3 clinical trials. [Published online ahead of print October 27, 2018]. Infect Dis Ther. doi:10.1007/s40121-018-0218-x.
This Week's Must Reads
Must Reads in Hepatitis
Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al
HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al
HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al
Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al
Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al