Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Glecaprevir/Pibrentasvir Tx in Renal & CV Outcomes

Infect Dis Ther; ePub 2018 Oct 27; Tran, et al

In patients with chronic hepatitis C (CHC) without cirrhosis, short-duration treatment with glecaprevir/pibrentasvir (G/P) resulted in stable renal function and improvements in cardiovascular (CV) and metabolic extrahepatic manifestation (EHM) markers, especially in those with severe EHMs at baseline. This according to a post-hoc analysis of 2 phase 3 clinical trials in patients without cirrhosis treated with G/P for 8 weeks. In addition, 1 phase 3 trial was carried out to explore the effects of treatment on renal EHMs in patients with advanced renal impairment at baseline. Researchers included all CHC patients treated with G/P for 8 or 12 weeks enrolled across 5, phase 3 trials as a sensitivity analysis. They found:

  • G/P treatment for 8 weeks resulted in statistically significant declines in triglycerides (‒28.6 mg/dL) and glucose (‒11.2 mg/dL), with no statistically significant decline in estimated glomerular filtration rate (eGFR).
  • Biomarker improvements were greatest among patients with elevated triglycerides and elevated glucose at baseline.
  • Similar effects were observed across all patients treated with G/P for 8 or 12 weeks.

Citation:

Tran TT, Mehta D, Mensa F, Park C, Bao Y, Sanchez Gonzalez Y. Pan-genotypic hepatitis C treatment with glecaprevir and pibrentasvir for 8 weeks resulted in improved cardiovascular and metabolic outcomes and stable renal function: A post-hoc analysis of phase 3 clinical trials. [Published online ahead of print October 27, 2018]. Infect Dis Ther. doi:10.1007/s40121-018-0218-x.

This Week's Must Reads

Androgen Deprivation Therapy & Risk of Depression, Cancer; ePub 2019 Feb 12; Deka, Rose, et al

QOL in Patients with Low-Risk PC Treated with HRT, JAMA Oncol; ePub 2019 Feb 14; Bruner, et al

Hospital Competition & Prostate Cancer Outcomes, Cancer; ePub 2019 Feb 1; Aggarwal, et al

Insurance Status & Stage of Prostate Ca Diagnosis, Cancer Epidemiol; 2019 Apr; Ramirez, Morano, et al

Agent Orange Exposure & Prostate Ca Outcomes, J Urol; ePub 2019 Jan 8; Etheridge, et al

Must Reads in Hepatitis

Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al

HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al

HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al

Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al

Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al