Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Glecaprevir/pibrentasvir Can Reduce HCV Tx Duration

Hepatol Int; ePub 2018 May 29; Abutaleb, et al

Publish date:: June 15, 2018

Glecaprevir/pibrentasvir (GLE/PIB) is a fixed-dose combination therapy approved for hepatitis C virus (HCV) that has expanded reach, reduced cost, and in certain patient populations, reduced HCV treatment duration, according to a recent review. The authors concluded:

GLE/PIB is effective across all genotypes.
GLE/PIB has been shown to be effective in HIV-infected patients, patients with chronic kidney disease (CKD), and Child-Pugh A-compensated cirrhosis.
GLE/PIB is also effective for a shortened duration of 8 weeks in treatment-naïve non-cirrhotic patients.

Citation:

Abutaleb A, Kottilil S, Wilson E. Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy. [Published online ahead of print May 29, 2018]. Hepatol Int. doi:10.1007/s12072-018-9873-y.

This Week's Must Reads

MRI Staging T3 Prostate Cancer: Do Coils Matter?,

Analysis of Gene Alterations in Patients with Advanced Prostate Cancer,

Local Failure and Survival After Radiotherapy for Aggressive Prostate Cancer,

Inpatient Care Patterns for Patients with Prostate Cancer and Spina Bifiida,

Decision Support Intervention Increases Patients Prostate Cancer Knowledge ,

Must Reads in Hepatitis

Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al

HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al

HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al

Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al

Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al