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Chronic HCV Prognosis in TE-based Liver Stiffness

J Viral Hepat; ePub 2018 Jan 24; Erman, et al

Transient elastrography (TE)-based liver stiffness may be used as an alternative to fibrosis progression rates (FPRs) to estimate chronic hepatitis C (CHC) prognosis, a recent study found. The meta-analysis estimated prognosis in treatment-naïve CHC patients using TE-based liver stiffness progression rates (LSPR) as an alternative to FPRs and to compare consistency between LSPRs and FPRs. Among the details:

  • 27 studies reporting on 39 groups of patients (n=5,874) were identified with 35 groups allowing for indirect and 8 for direct estimation of LSPR.
  • ~58% of patients were HIV/HCV coinfected.
  • The estimated time-to-cirrhosis based on TE vs biopsy was 39 and 38 years, respectively.
  • Non-invasive prognosis of HCV is consistent with FPRs in predicting time-to-cirrhosis.


Erman A, Sathya A, Nam A, et al. Estimating chronic hepatitis C prognosis using transient elastography-based liver stiffness: A systematic review and meta-analysis. [Published online ahead of print January 24, 2018]. J Viral Hepat. doi:10.1111/jvh.12846.

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