Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Chronic HCV Prognosis in TE-based Liver Stiffness

J Viral Hepat; ePub 2018 Jan 24; Erman, et al

Transient elastrography (TE)-based liver stiffness may be used as an alternative to fibrosis progression rates (FPRs) to estimate chronic hepatitis C (CHC) prognosis, a recent study found. The meta-analysis estimated prognosis in treatment-naïve CHC patients using TE-based liver stiffness progression rates (LSPR) as an alternative to FPRs and to compare consistency between LSPRs and FPRs. Among the details:

  • 27 studies reporting on 39 groups of patients (n=5,874) were identified with 35 groups allowing for indirect and 8 for direct estimation of LSPR.
  • ~58% of patients were HIV/HCV coinfected.
  • The estimated time-to-cirrhosis based on TE vs biopsy was 39 and 38 years, respectively.
  • Non-invasive prognosis of HCV is consistent with FPRs in predicting time-to-cirrhosis.


Erman A, Sathya A, Nam A, et al. Estimating chronic hepatitis C prognosis using transient elastography-based liver stiffness: A systematic review and meta-analysis. [Published online ahead of print January 24, 2018]. J Viral Hepat. doi:10.1111/jvh.12846.

This Week's Must Reads

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al

Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al

Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Must Reads in Hepatitis

Treatment Uptake for HCV in VA Healthcare System, Clin Infect Dis; ePub 2018 Aug 22; Butt, et al

Prevalence of HCV Among Baby Boomers in US, J Infect Public Health; ePub 2018 Aug 28; Moore, et al

Universal Screening for Chronic HCV Infection, Clin Gastroenterol Hepatol; ePub 2018 Sep 7; Eckman, et al

Health-Related QOL in HIV/HCV Coinfected Patients, J Viral Hepat; ePub 2018 Aug 23; Saeed, et al

HCV Testing of PWID in High-Prevalence Settings, J Viral Hepat; ePub 2018 Jul 26; Scott, et al