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Chronic HCV & Early HIV Viral Response to ART

AIDS; ePub 2018 Jan 13; Willis, Cole, et al

Chronic hepatitis C virus (HCV) infection may negatively impact early human immunodeficiency virus (HIV) viral response to antiretroviral therapy (ART), a recent study found. HIV RNA was measured every 6 months among 441 women with HIV (WWH) in the Women’s Interagency HIV Study who initiated ART from 2000-2015. Log-binomial regression models were used to compare the proportion of study visits with detectable HIV RNA between women with and without chronic HCV. Researchers found:

  • 114 (25%) women had chronic HCV before ART initiation.
  • The proportion of visits with detectable HIV RNA was similar among women with and without chronic HCV (risk ratio, 1.19).
  • 6 months after ART initiation, the proportion of visits with detectable HIV RNA among women with chronic HCV was 1.88 times that among women without HCV.
  • At 2 years the ratio was 1.60, and by 6 years there was no difference.

Citation:

Willis SJ, Cole SR, Westreich D, et al. Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy. [Published online ahead of print January 13, 2018]. AIDS. doi:10.1097/QAD.0000000000001745.