Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

The Value of Ruxolitinib Before and After AlloSCT

Blood; ePub 2017 Dec 7; Poulose, Malysz, et al

Ruxolitinib treatment was well tolerated before and after allogeneic stem cell transplant (alloSCT) in a small retrospective analysis involving 15 individuals with myelofibrosis. Investigators looked at alloSCT outcomes in participants with myelofibrosis who—along with reduced intensity conditioning—received ruxolitinib before and after alloSCT (n=4), prior to alloSCT (n=7), or not at all (n=4). Among the results:

  • Ruxolitinib was administered an average 8.3 months before and 12.5 months post-alloSCT.
  • Average neutrophils engraft days for patients who received ruxolitinib before and after alloSCT was 13.3 days.
  • The averages for those who received ruxolitinib before alloSCT or did not receive it were 13.6 and 16 days, respectively.
  • Average spleen size reductions 6 months after alloSCT were 26%, 18%, and 18%, respectively.
  • All patients were reported alive and in complete remission.

Citation:

Poulose J, Malysz J, Claxton D, et al. Impact of ruxolitinib in myelofibrosis allogeneic stem cell transplant outcome: A pilot study. [Published online ahead of print December 7, 2017]. Blood. 130 (Suppl 1), 5543.

This Week's Must Reads

Treating Low-Risk Patients with Mild Hypertension, JAMA Intern Med; ePub 2018 Oct 29; Sheppard, et al

Short Interpregnancy Intervals & Pregnancy Outcomes, JAMA Intern Med; ePub 2018 Oct 29; Schummers, et al

Peer Support Impact in Adults with T2D & Depression, Diabetes Care; ePub 2018 Oct 29; Cherrington, et al

Efficacy of Bariatric Procedures for Weight Loss, Ann Intern Med; ePub 2018 Oct 30; Arterburn, et al

Concomitant DOAC-Antiplatelet Use & Bleeding Risk, Am J Med; ePub 2018 Oct 25; Douros, et al

Must Reads in Hematologic Malignancies

Long-term ibrutinib data in older patients, Barr PM et al. Haematologica. 2018;103(9):1502-10

Prognostic Score System for Patients with PMF, J Clin Oncol; ePub 2017 Dec 9; Gugliemelli, et al

These Patients Are More Apt to Be Depressed, Ann Hematol; ePub 2017 Dec 7; Shreders, et al

Survival Length Shortest in These Patients with MF, Eur J Haematol; ePub 2017 Dec 11; Masarova, et al

The Value of Ruxolitinib Before and After AlloSCT, Blood; ePub 2017 Dec 7; Poulose, Malysz, et al