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Hospitalization Rates in Young-Onset Diabetes

Ann Intern Med; ePub 2019 Jan 15; Ke, Lau, et al

In a population-based cohort study, adults with young-onset diabetes (YOD) experienced excess hospitalizations across their lifespan compared with those with usual-onset type 2 diabetes (T2D), including a large burden of mental illness in young adulthood. Adults aged 20-75 years in population-based (2002 to 2014; n=422,908) and registry-based (200 to 2014; n=20,886) T2D cohorts were included. Researchers sought to determine hospitalization rates among persons with YOD and to examine the effect of age at onset on hospitalization risk. Primary outcomes were all-cause and cause-specific hospitalization rates. They found:

  • Patients with YOD had the highest hospitalization rates by attained age.
  • In the registry cohort, 36.8% of YOD bed-days before age 40 years were due to mental illness.
  • Adjusted rate ratios showed increased hospitalization in YOD vs usual-onset T2D (all-cause, 1.8; renal, 6.7; diabetes, 3.7; cardiovascular, 2.1; infection, 1.7).


Ke C, Lau E, Shah BR, et al. Excess burden of mental illness and hospitalization in young-onset type 2 diabetes: A population-based cohort study. [Published online ahead of print January 15, 2019]. Ann Intern Med. doi:10.7326/M18-1900.