Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CKD-MBD Clinical Practice Guideline Update

Ann Intern Med; ePub 2018 Feb 20; Ketteler, et al

The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease –mineral and bone disorder (CKD-MBD) is intended to assist practitioners caring for adults with CKD and those receiving long-term dialysis. The update includes the revision of 15 recommendations. This synopsis focuses primary on:

  • Recommendations for diagnosis and treatment of CKD-MBD that emphasizes decreasing phosphate levels, maintaining calcium levels, and addressing elevated parathyroid hormone levels in adults with CKD state G3a to G5 and those receiving dialysis.
  • Key elements include basing treatment or trends in laboratory values rather than in a single abnormal result and being cautious to avoid hypercalcemia when treating secondary hyperparathyroidism.

The complete 2017 update is available at www.kdigo.org.

Citation:

Ketteler M, Block GA, Evenepoel P, et al. Diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline update. Ann Intern Med. [Published online ahead of print February 20, 2018]. doi:10.7326/M17-2640.

This Week's Must Reads

Global Burden of CVD in People Living with HIV, Circulation; ePub 2018 Jul 2; Shah, et al

Penicillin Allergy & Risk of MRSA and C. difficle, BMJ; ePub 2018 Jun 27; Blumenthal, et al

Does Sleep Debt Decrease with Age? , Sleep Health; ePub 2018 Jun 28; Fox, et al

Firearm Injuries in Children & Adolescents, Pediatrics; ePub 2018 Jul 2; Herrin, et al

Effects of Pulse Pressure & BP Tx Intensity on AEs, Am J Med; ePub 2018 Jun 22; Krishnaswami, et al

Must Reads in Clinical Guidelines

Screening for Osteoporosis to Prevent Fractures, JAMA; ePub 2018 Jun 26; US Preventive Services Task Force

ECG Screening for CVD in Low-Risk Patients, JAMA; 2018 Jun 12; Curry, US Preventive Task Force

ACS Recommends CRC Screening at Age 45, CA Cancer J Clin; ePub 2018 May 30; Wolf, et al

USPSTF: Screening for Prostate Cancer, JAMA; 2018 May 8; Grossman, et al

USPSTF Recommendation on Falls Prevention, JAMA; ePub 2018 Apr 17; US Preventive Services Task Force