In adults aged ≥50 years, supplementation with vitamin D did not result in a lower incidence of invasive cancer or cardiovascular (CV) events then placebo, a new study found. Researchers conducted a nationwide, randomized, placebo-controlled trial of vitamin D3 at a dose of 2000 IU per day and marine n-3 (omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and CVD among men aged ≥50 years and women aged ≥55 years in the US. Primary end points were invasive cancer of any type and major CV events. Among the findings:
- 25,871 participants (5,106 black), underwent randomization.
- Supplementation with vitamin D was not associated with a lower risk of either the primary end points.
- During a median follow-up of 5.3 years, cancer was diagnosed in 1,617 participants (793 in the vitamin D group and 824 in the placebo group; HR, 0.96).
- A major CV event occurred in 805 participants (396 in the vitamin D group vs 409 in the placebo group; HR, 0.97).
Manson JE, Cook NR, Lee IM, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. [Published online ahead of print November 10, 2018]. N Engl J Med. doi:10.1056/NEJMoa1809944.
This Week's Must Reads
Androgen Deprivation Therapy & Risk of Depression, Cancer; ePub 2019 Feb 12; Deka, Rose, et al
QOL in Patients with Low-Risk PC Treated with HRT, JAMA Oncol; ePub 2019 Feb 14; Bruner, et al
Hospital Competition & Prostate Cancer Outcomes, Cancer; ePub 2019 Feb 1; Aggarwal, et al
Insurance Status & Stage of Prostate Ca Diagnosis, Cancer Epidemiol; 2019 Apr; Ramirez, Morano, et al
Agent Orange Exposure & Prostate Ca Outcomes, J Urol; ePub 2019 Jan 8; Etheridge, et al
Must Reads in Cardiology
AHA Statement: Accurate Measurement of BP, Hypertension; ePub 2019 Mar 4; Muntner, et al
Is Adding Aspirin to Warfarin Therapy Beneficial? , JAMA Intern Med; ePub 2019 Mar 4; Schaefer, et al
Psychosocial Stress & CV Health in Older Women, Circulation; ePub 2019 Feb 28; Burroughs-Peña, et al
AHA Statement: CV Risk Reduction in Pediatrics, Circulation; ePub 2019 Feb 25; de Ferranti, et al
Sedentary Behaviors & CVD Risk in Older Women, Circulation; 2019 Feb 19; Bellettiere, et al