Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Aspirin for Prevention of CV Events

JAMA; 2019 Jan 22; Zheng, Roddick

The use of aspirin in individuals without cardiovascular disease (CVD) was associated with a lower risk of CV events and an increased risk of major bleeding, a new study found. The systematic review and meta-analysis of included 13 trials with 164,225 participants without CVD (median age 62 years, 19% had diabetes). Researchers assessed the association of aspirin use for primary prevention with CV events and bleeding. The primary CV outcome was a composite of CV mortality, nonfatal myocardial infarction, and nonfatal stroke. The primary bleeding outcome was any major bleeding. Among the findings:

  • Participant median baseline risk of the primary CV outcome was 9.2%.
  • Aspirin use was associated with significant reductions in the composite CV outcome compared with no aspirin.
  • Aspirin use was also associated with an increased risk of major bleeding events compared with no aspirin.

Citation:

Zheng SL, Roddick AJ. Association of aspirin use for primary prevention with cardiovascular events and bleeding events: A systematic review and meta-analysis. JAMA. 2019;321(3):277–287. doi:10.1001/jama.2018.20578.

This Week's Must Reads

ACIP Updates Adult Immunization Schedule, Ann Intern Med; 2019 Feb 5; Kim, Hunter, et al

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

Prevention of Prescription Opioid Misuse in the US, JAMA Netw Open; 2019 Feb 1; Chen, et al

E-cigarettes & Risk of Tobacco Cigarette Initiation, JAMA Netw Open; 2019 Feb 1; Berry, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al

Must Reads in Cardiology

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Aspirin for Prevention of CV Events, JAMA; 2019 Jan 22; Zheng, Roddick

Educational Attainment & CV Risk in Hispanic Persons, JAMA Cardiol; 2019 Jan; Rodriguez, Leonard, et al