Clinical Edge

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Radical Prostatectomy: Circulating MicroRNAs in Plasma Before and After Surgery

Key clinical point: Determining if circulating miRNAs in plasma could be employed as biomarkers of disease among men treated for prostate cancer (PCa) by radical prostatectomy (RP).

Major finding: There was no significant change in the expression of circulating miRNAs in plasma from before to approximately 2 months after surgery.

Study details: The expression of 17 preselected circulating miRNAs associated with PCa or high-grade PCa in plasma at prostate biopsy was examined in pre- and post-RP plasma of 29 men, aged 43 - 77 years using real-time PCR and compared using Wilcoxon signed-ranked test.


McDonald AC, et al. Urol Oncol. 2019 Aug 14. doi: 10.1016/j.urolonc.2019.07.001.