Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Intraprostatic Inflammation, Focal Atrophy, and Progression to Lethal Prostate Cancer

Key clinical point: The presence of inflammation, particularly chronic inflammation, in prostate cancer tissue is associated with better prognosis among patients with prostate cancer.

Major finding: During a 12 years of follow-up, 153 men developed lethal prostate cancer, and 84% had histologic evidence of chronic inflammation and 30% had acute inflammation.

Study details: 1,035 men diagnosed with prostate cancer were studied, and a genitourinary pathologist reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and 4 subtypes of focal atrophy.


Zhang Y, et al. Cancer Epidemiol Biomarkers Prev. 2019 Sep 18. doi: 10.1158/1055-9965.EPI-19-0713.