Original Research

Perceived Barriers and Facilitators of Clozapine Use: A National Survey of Veterans Affairs Prescribers

Although health care providers report that the frequent laboratory monitoring requirement is an unavoidable concern, other barriers, such as logistical concerns and the administrative burden that accompanies clozapine use, can be addressed.

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Clozapine is an atypical antipsychotic that the US Food and Drug Administration (FDA) approved for use in schizophrenia and suicidality associated with schizophrenia or schizoaffective disorder. Clozapine has been shown to be superior to other antipsychotic treatment for treatment resistant schizophrenia (TRS), which is defined as failure of 2 adequate trials of antipsychotic therapy. 1 Up to 30% of patients with schizophrenia are classified as treatment resistant. 2

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