Case Reports

Testicular Swelling as an Initial Presentation of a Patient With Metastatic Gastric Cancer

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While signet-ring cell morphology in the testes might represent metastatic spread from an extragonadal adenocarcinoma, a rare variant of primary testicular neoplasms should be considered in a differential diagnoses as was seen in this rare occurrence of a testicular swelling as an initial presentation for a patient with metastatic gastric cancer.



Gastric cancer is one of the most common cancers and the second most common cause of cancer-related death worldwide. 1 Patients with an early-stage gastric cancer are often asymptomatic, and about 30% to 40% of patients present with distant metastases. 2 The most common sites of metastasis are the liver, peritoneum, and the lymph nodes. In more advanced stages, gastric cancers spread to the lungs, brain, bones, soft tissues, and other sites. Krukenberg tumors are classic but rare occurrences of gastric cancer metastasis to ovaries in females. In men, it is rare for gastric cancer to metastasize to the testes. Only a few cases of testicular metastasis from gastric cancer have been reported in the literature. 3-5

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