Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Breast Biopsy Rates Following BC Screening

JAMA Intern Med; 2018 Apr; Buist, et al

Women with and without a personal history of breast cancer (PHBC) who undergo screening magnetic resonance imaging (MRI) experience higher biopsy rates coupled with significantly lower cancer yield compared with screening mammography alone, a recent study found. The population-based cohort included 812,164 women undergoing screening (mammography vs MRI with or without mammography) from 2003 through 2013. A total of 2,048,994 digital mammography and/or breast MRI screening episodes were observed. Researchers found:

  • Age-adjusted core and surgical biopsy rates per 1,000 episodes doubled following MRI compared with mammography in women with PHBC.
  • Differences were even larger in women without PHBC: 84.7 following MRI and 14.9 following mammography episodes.
  • Lower invasive cancer and ductal carcinoma in situ yield for both groups was observed.
  • Higher biopsy rates and lower cancer yield following MRI was not explained by increasing age or higher 5-year breast cancer risk.

Citation:

Buist DSM, Abraham L, Lee CI, et al. Breast biopsy intensity and findings following breast cancer screening in women with and without a personal history of breast cancer. JAMA Intern Med. 2018;178(4):458–468. doi:10.1001/jamainternmed.2017.8549.

This Week's Must Reads

HRRP & Patient Mortality in HF, AMI & Pneumonia, JAMA; 2018 Dec 25; Wadhera, et al

Hypertensive Diseases of Pregnancy & Risk of HF, Mayo Clin Proc; ePub 2018 Dec 19; Nizamuddin, et al

Clopidogrel + Aspirin Can Reduce Recurrent Stroke, BMJ; ePub 2018 Dec 18; Hao, Tampi, et al

Second-Line ADMs & CV Events in T2D, JAMA Netw Open; ePub 2018 Dec 21; O’Brien, et al

Health Care Utilization of a Dementia Care Program, JAMA Intern Med; ePub 2018 Dec 21; Jennings, et al

Must Reads in Oncology

Does Vitamin D Reduce Cancer & CVD Risk?, N Engl J Med; ePub 2018 Nov 10; Manson, et al

Interventions to Increase CRC Screening Rates, JAMA Intern Med; ePub 2018 Oct 15; Dougherty, et al

Smoking & Lung Cancer Mortality in the US to 2065, Ann Intern Med; ePub 2018 Oct 9; Jeon, et al

Dietary Indexes and Risk of Colorectal Cancer, Am J Clin Nutrit; ePub 2018 Oct 4; Petimar, et al

FIT Performance & Optimal Positivity Thresholds, Ann Intern Med; ePub 2018 Sep 18; Selby, et al