Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Effect of Fish Oil Supplementation in Pregnancy

BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Fish oil supplementation from the 24th week of pregnancy led to a higher body mass index (BMI) in the offspring from age 0-6 years but not an increased risk of obesity at age 6. This according to the results from a randomized clinical trial of 736 pregnant women and their offspring that examined the effect of supplementation with n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) in pregnancy on anthropometry and body composition in offspring. Participants were randomized to either n-3 LCPUFA (fish oil) or control (olive oil) daily from pregnancy week 24 until 1 week after birth. Among the findings:

  • n-3 LCPUFA supplementation in pregnancy led to increased BMI in childhood, with sustained elevated BMI from age 1-6 years.
  • There was no difference in fat percentage.
  • However, a proportional increase in lean mass, bone mass, and fat mass was observed at age 6 years.


Vinding RK, Stokholm J, Sevelsted A, et al. Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: Randomised clinical trial. [Published online ahead of print September 4, 2018]. doi:10.1136/bmj.k3312.

This Week's Must Reads

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

BMI & Risk of Postpregnancy T2D in Women with HDP , Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Diabetes Outcomes in Patients by PCPs, NPs, or PAs, Ann Intern Med; ePub 2018 Nov 20; Jackson, et al

Traumatic Exposures & Health Issues in Older Women, JAMA Intern Med; ePub 2018 Nov 19; Gibson, et al

Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al

Must Reads in Obesity

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

Early Antibiotic Use & Weight Outcomes in Children, Pediatrics; ePub 2018 Oct 31; Block, Bailey, et al

Efficacy of Bariatric Procedures for Weight Loss, Ann Intern Med; ePub 2018 Oct 30; Arterburn, et al

Bariatric Surgery & Macrovascular Disease in T2D, JAMA; 2018 Oct 16; Fisher, Johnson, et al

Adverse Childhood Experiences & Weight Status, J Pediatr; ePub 2018 Oct 1; Davis, Barnes, et al