Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Association of BMI with Lifetime Risk of CVD

JAMA Cardiol; ePub 2018 Feb 28; Khan, et al

Compared to normal body mass index (BMI), obesity and overweight are associated with significantly increased risk of cardiovascular disease (CVD), according to a recent population-based study. The study calculated lifetime risk of incident CVD and subtypes of CVD and estimated years lived with and without CVD by weight status. Among the details:

  • Of the 190,672 in-person examinations included, the mean (SD) age was 46.0 years (15.0) years for men and 58.7 (12.9) for women, and 140,835 patients (73.0%) were female.
  • Obesity was associated with shorter longevity and a greater proportion of life lived with CVD.
  • Overweight was associated with similar longevity as normal weight but at the expense of a greater proportion of life lived with CVD.


Khan SS, Ning H, Wilkins JT, et al. Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity. [Published online ahead of print February 28, 2018]. JAMA Cardiol. doi:10.1001/jamacardio.2018.0022.

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