Nearly 1 in 12 US children and adolescents are concurrent users of prescription medications and are at risk for a major drug-drug interaction (DDI), a recent study suggests. Researchers estimated the prevalence of prescription medication use, concurrent use, and potential DDIs in children and adolescents (aged ≤19 years) in the US. Concurrent use was defined as use of ≥2 prescription medications. They found:
- During 2013-2014, 19.5% of children and adolescents in the study population used at least 1 prescription medication, 7.1% used acute medications.
- Concurrent use of prescription medications was 7.5% overall and was highest among boys aged 6-12 years (12%) and among boys and girls aged 13-19 years (10% for both).
- Using pooled 2009-2014 data, researchers found that 8.2% of concurrent users of prescription medications were at risk for a potentially major DDI.
- The vast majority of interacting regimens involved antidepressants and were more common among adolescent girls than boys.
Qato DM, Alexander GC, Guadamuz JS, Lindau ST. Prescription medication use among children and adolescents in the United States. [Published online ahead of print August 27, 2018]. Pediatrics. doi:10.1542/peds.2018-1042.
This Week's Must Reads
Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators
Outpatient Care for Adults With Primary Care, JAMA Intern Med; ePub 2019 Jan 28; Levine, et al
Antibiotic Therapy in Patients with Asthma, JAMA Intern Med; ePub 2019 Jan 28; Stefan, et al
Outpatient Benzodiazepine Prescribing in US, JAMA Netw Open; 2019 Jan 25; Agarwal, et al
Reduction of Readmissions Through Primary Care, JAMA Netw Open; 2019 Jan 25; Wiest, et al
Must Reads in Pediatrics
Appropriateness of Outpatient Antibiotic Prescribing , BMJ; ePub 2019 Jan 16; Chua, Fischer, et al
Assessing the Diet Quality of US Children, Am J Clin Nutrit; ePub 2018 Dec 29; Thomson, et al
Trends in Pediatric Outpatient Antibiotic Use, Pediatrics; ePub 2018 Dec 17; Finkelstein, et al
Predicting Asthma Development in Young Children, J Allergy Clin Immunol; ePub 2018 Dec 13; Biagini Myers, et al
Intake Disparities in Sugar-Sweetened Beverages, Am J Clin Nutr; ePub 2018 Dec 7; Mendez, et al