Key clinical point: Mucus buildup in the lungs was found to precede structural damage and infection in toddlers with cystic fibrosis (CF).
Major finding: Bronchoalveolar lavage fluid total mucin levels were higher in CF samples versus non-CF controls.
Study details: A cross-sectional cohort study of 46 children with CF.
Disclosures: Funding from the National Heart, Lung, and Blood Institute; the North Carolina Translational and Clinical Sciences Institute; the National Health and Medical Research Council; and the Cystic Fibrosis Foundation. Two coauthors reported financial affiliations with Parion Sciences.
Esther CR et al. Sci Transl Med. 2019 Apr 3. doi: 10.1126/scitranslmed.aav3488.