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Methotrexate Significantly Reduced Knee OA Pain

Key clinical point: Oral methotrexate achieved significant reductions in knee osteoarthritis pain, stiffness, and functional impairment.

Major finding: The standard effect size for methotrexate in terms of pain reduction was 0.36, considered to be moderate.

Study details: This multicenter, randomized, double-blind, placebo-controlled clinical trial included 134 patients evaluated at 6 months.

Disclosures: The presenter reported having no financial conflicts regarding the PROMOTE trial, which was funded by the U.K. National Institute for Health Research and Versus Arthritis.

Citation:

Conaghan PG et al. OARSI 2019, Abstract 86.