Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Dietary Indexes and Risk of Colorectal Cancer

Am J Clin Nutrit; ePub 2018 Oct 4; Petimar, et al

Adherence to the Dietary Approaches to Stop Hypertension (DASH), Alternative Mediterranean Diet (AMED), and Alternative Healthy Easting Index-2010 (AHEI-2010) diets was inversely associated with colorectal cancer (CRC) risk in men, but not in women, in a recent analysis of 2 prospective cohort studies. Researchers followed 78,012 women in the Nurses’ Health Study and 46,695 men in the Health Professionals Follow-Up Study from 1986 and 1988, respectively, until 2012. They created dietary index scores for DASH, AMED, and AHEI-2010 to determine associations between adherence to various dietary indexes and incident CRC. They found:

  • 2,690 CRC cases were documented.
  • Pooled multivariable hazard ratios (HRs) for CRC risk comparing the highest to lowest quintile of diet scores were 0.89 for DASH, 0.89 for AMED, and 0.95 for AHEI-2010.
  • There were stronger associations in men for all dietary indexes than in women.


Petimar J, Smith-Warner SA, Fung TT, et al. Recommendation-based dietary indexes and risk of colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study. [Published online ahead of print October 4, 2018]. Am J Clin Nutrit. doi:10.1093/ajcn/nqy171.