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One postdelivery antibiotic dose nearly halves infection in operative delivery

Knight M. et al. Am J Obstet Gynecol 2019 Jan;220;1:S685. Abstract LB 3.

Key clinical point: A single postdelivery dose of intravenous amoxicillin-clavulanic acid significantly reduced infections after operative delivery.

Major finding: The risk ratio for probable or confirmed infection was 0.58 for those receiving prophylactic postdelivery amoxicillin-clavulanic acid (95% CI, 0.49-0.69, P less than .001).

Study details: Multisite, randomized, blinded, placebo-controlled trial of 3,427 term deliveries.

Disclosures: The United Kingdom’s National Institute for Health Research sponsored the study. Dr. Knight reported no conflicts of interest.