Clinical Edge

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Faster enteral feeding does not up adverse outcomes risk in preterm infants

Key clinical point: Feeding preterm or low-birth-weight infants a faster increment of daily milk does not appear to increase their risk of developing adverse outcomes.

Major finding: 65.5% of infants in the faster-increment group and 68.1% of infants in the slower-increment group achieved an outcome of survival without moderate or severe neurodevelopmental disability at 24 months.

Study details: A randomized controlled trial of 2,804 preterm or low-birth-weight infants who received milk volume in faster and slower increments until they reached full feeding volume.

Disclosures: This study was funded by the Health Technology Assessment Programme of the National Institute for Health Re-search. The authors reported various relationships with Baxter Bioscience, Chiesi Farmaceutici, Danone Early Life Nutrition, Fresenius Kabi USA, National Institute for Health Research, Nestle Nutrition Institute, Nutrina, Medical Research Council, and Prolacta Biosciences in the form of consultancies, grants, travel reimbursement, board memberships, and editorial board appointments.


Doring J et al. N Eng J Med. 2019. doi: 10.1056/NEJMoa1816654.