Antiretroviral therapy (ART) resulting in long-term viral suppression may contribute to cancer prevention, a recent study suggests. In this prospective cohort, researchers sought to determine whether viral suppression is associated with decreased cancer risk in HIV-positive veterans (n=42,441) demographically matched to uninfected veterans (n=104,712) from 1999 to 2015. They found:
- Cancer incidence for HIV-positive vs uninfected persons was highest for unsuppressed persons, lower among persons with early suppression, and lowest among those with long-term suppression.
- This trend was strongest for AIDS-defining cancer (ADC), much weaker for non-AIDS-defining cancer (NADC), and absent for NADC not caused by viruses.
- Patients with long-term viral suppression still had excess cancer risk.
Park LS, Tate JP, Sigel K, et al. Association of viral suppression with lower AIDS-defining and non–AIDS-defining cancer incidence in HIV-infected veterans: A prospective cohort study. [Published online ahead of print June 12, 2018]. Ann Intern Med. doi:10.7326/M16-2094.
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Umbilical cord milking tied to severe IVH in very premature neonates, Katheria AC et al. The Pregnancy Meeting, late breaking abstract 1.
Ehlers-Danlos syndrome: Increased IUGR risk reported, Nicholls-Dempsey L et al. Am J Obstet Gynecol. 2019 Jan;220(1):S381-382. Abstract 574
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Must Reads in Infectious Diseases
Prescribed Opioids & Risk of CAP in Patients with HIV, JAMA Intern Med; 2019 Jan 7; Edelman, et al
Influenza Vaccination Safety During Hospitalization, Mayo Clin Proc; ePub 2019 Jan 8; Tartof, et al
Hospitalization Trends for Drug-Use Associated IE, Ann Intern Med; ePub 2018 Dec 4; Schranz, et al
Healthcare-Associated Infections in US Hospitals, N Engl J Med; 2018 Nov 1; Magill, O’Leary, et al
Gaps in HIV PrEP by Race and Ethnicity, MMWR; 2018 Oct 19; Huang, Zhu, et al