Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Trends in HPV-Associated Cancers in the US

MMWR; 2018 Aug 24; Van Dyne, Henley, et al

From 1999 to 2015, human papillomavirus (HPV)-associated cancer rates changed in the US, with oropharyngeal squamous cell carcinoma (SCC) now the most common HPV-associated cancer. The Centers for Disease Control and Prevention (CDC) analyzed data from cancer registries covering 97.8% of the US population. It found:

  • There were 30,115 new cases of HPV-associated cancers in 1999 and 43,371 in 2015.
  • During the study period, cervical carcinoma incidence cancer rates decreased by 1.6%.
  • Oropharyngeal SCC incidence rates increased 2.7% per year during the same time period among men and 0.8% per year among women.

Although population-based screening is recommended for only 1 HPV-associated cancer (cervical) at this time, the authors offer that HPV vaccination can prevent infection with the HPV types most strongly associated with cancer.

Citation:

Van Dyne EA, Henley SJ, Saraiya M, Thomas CC, Markowitz LE, Benard VB. Trends in human papillomavirus–associated cancers—United States, 1999–2015. MMWR Morb Mortal Wkly Rep 2018;67:918–924. doi:10.15585/mmwr.mm6733a2.

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