Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

GERD: Endoscopic therapies may offer alternative to PPIs

Key clinical point: For patients with gastroesophageal reflux disease, endoscopic and minimally invasive surgical techniques may serve as viable alternatives to proton pump inhibitor therapy.

Major finding: Magnetic sphincter augmentation, radiofrequency ablation, and transoral incisionless fundoplication had the most evidence in previous trials.

Study details: A scoping review of randomized, controlled trials and observational studies involving endoscopic therapies in gastroesophageal reflux disease.

Disclosures: The investigators reported no conflicts of interest.


Vaezi MF et al. Gastroenterology. 2020 Jul 1. doi: 10.1053/j.gastro.2020.05.097.