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Enterovirus in at-risk children associated with later celiac disease

Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

Key clinical point: Children with increased genetic risk of celiac disease could have it triggered by an enterovirus infection at an early age.

Major finding: There was significant association between later development of celiac disease and both enterovirus A (adjusted odds ratio, 1.62; 95% confidence interval, 1.04-2.53; P = .03) and enterovirus B (aOR, 2.27, 95% CI, 1.33-3.88; P = .003).

Study details: A case-control study of 220 children nested within a Norwegian birth cohort of newborns with the HLA-DQ2/DQ8 genotype.

Disclosures: The study was funded by the Research Council of Norway, the Project for the Conceptual Development of Research Organization, and the Norwegian Coeliac Society. Two authors reported grant support from trusts and foundations in Norway and Switzerland; no conflicts of interest were reported.

Citation:

Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231.