Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Bethesda system underpredicts malignancy in pediatric thyroid tumors

Key clinical point: Pediatric thyroid nodule cytopathology classified according to the Bethesda system showed a higher rate of malignancy than that reported in adults.

Major finding: Of 203 nodules, 14 were Bethesda category IV (follicular neoplasm or suspicious for neoplasm), and 42.9% of those were malignant, compared with the 25%-40% expected in adults.

Study details: Retrospective, single-center review of 203 fine needle–aspirated samples from 171 pediatric patients with thyroid nodules tracked over a 16-year period.

Disclosures: Dr. Jiang reported no relevant conflicts of interest and no outside sources of funding.


Johnson T et al. ATA 2019, Oral Abstract 34.