Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

PPIs associated with diabetes risk, but questions remain

Key clinical point: Patients taking PPIs may be at increased risk of developing diabetes.

Major finding: PPI use was associated with a 24% increased risk of diabetes.

Study details: Analysis of three prospective cohorts: The Nurses’ Health Study (80,500 women), the Nurses’ Health Study II (95,550 women), and the Health Professionals Follow-up Study (28,639 men).

Disclosures: The study was funded by Sun Yat-sen University; the National Heart, Lung, and Blood Institute; and the National Institute of Diabetes and Digestive and Kidney Diseases.


Yuan J et al. Gut. 2020 Sep 28. doi: 10.1136/gutjnl-2020-322557.