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GD & Maternal Disorders of Glucose Metabolism

JAMA; 2018 Sep 11; Lowe, Scholtens, et al

Among women with gestational diabetes (GD) identified by contemporary criteria compared with those without it, GD was significantly associated with a higher maternal risk of a disorder of glucose metabolism during long-term follow-up after pregnancy. This according to an international multiethnic cohort study of 4,697 women and 4,832 children that examined the associations of GD with maternal glucose metabolism and childhood adiposity 10 to 14 years’ postpartum. The primary maternal outcome was a disorder of glucose metabolism and the primary outcome for children was being overweight or obese. Researchers found:

  • GD defined post hoc was significantly associated with maternal development of a disorder of glucose metabolism (composite of type 2 diabetes or prediabetes; odds ratio, 3.44).
  • GD was not significantly associated with the composite outcome of childhood overweight or obesity.


Lowe WL, Scholtens DM, Lowe LP, et al. Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity. JAMA. 2018;320(10):1005–1016. doi:10.1001/jama.2018.11628.