Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

SSRIs May Reduce Fecundability, Live Birth Rate in Reproductive-Age Women

Key clinical point: SSRIs were associated with reduced fecundability and live birth rate in women of reproductive age.

Major finding: SSRIs reduced fecundability by approximately 23% and the live birth rate by approximately 10%; patients taking fluoxetine also experienced a higher rate of pregnancy loss than patients taking other SSRIs.

Study details: A longitudinal exposure assessment of 1,228 women trying to conceive in the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial.

Disclosures: Dr. Sjaarda reported no relevant conflicts of interest.


Sjaarda L et al. ASRM 2019, Abstract O-1.