Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Omega 3 Polyunsaturated Fatty Acids & Healthy Aging

BMJ; ePub 2018 Oct 17; Lai, Otto, et al

Increased daily consumption of omega 3 polyunsaturated fatty acids (n3-PUFAs) from seafood is associated with a higher likelihood of healthy aging, according to a new study. The prospective cohort study included 2,622 adults with a mean age of 74.4 years from 4 communities in the US and with successful healthy aging at baseline in 1992-1993. Cumulative levels of plasma phospholipid n3-PUFAs were measured in 1992-1993, 1998-1999, and 2005-2006, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafood. Healthy aging was defined as survival without chronic diseases, the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy aging outcome after age 65. Among the findings:

  • Higher levels of serially measured circulating n3-PUFAs from seafood were associated with a lower risk of unhealthy aging after multivariable adjustments.
  • Increased dietary consumption of n3-PUFAs in older adults is recommended.


Lai HTM, Otto MC, Lemaitre RN, et al. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: Prospective cohort study. [Published online ahead of print October 17, 2018]. BMJ. doi:10.1136/bmj.k4067.

This Week's Must Reads

Umbilical cord milking tied to severe IVH in very premature neonates, Katheria AC et al. The Pregnancy Meeting, late breaking abstract 1.

Ehlers-Danlos syndrome: Increased IUGR risk reported, Nicholls-Dempsey L et al. Am J Obstet Gynecol. 2019 Jan;220(1):S381-382. Abstract 574

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Outpatient Care for Adults With Primary Care, JAMA Intern Med; ePub 2019 Jan 28; Levine, et al

Antibiotic Therapy in Patients with Asthma, JAMA Intern Med; ePub 2019 Jan 28; Stefan, et al

Must Reads in Cardiology

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Aspirin for Prevention of CV Events, JAMA; 2019 Jan 22; Zheng, Roddick

Educational Attainment & CV Risk in Hispanic Persons, JAMA Cardiol; 2019 Jan; Rodriguez, Leonard, et al

Long-Term Absolute Risk for CVD by FG Level, Diabetes Care; ePub 2019 Jan 7; Bancks, et al

Do Vitamin D Supplements Prevent Cancer, CVD?, N Engl J Med; 2019 Jan 3; Manson, Cook, et al