Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Myeloma therapies raise cardiovascular risks

Key clinical point: Drugs commonly used to treat multiple myeloma carry cardiovascular risks that should be carefully monitored.

Major finding: Cardiovascular adverse events occurred in 33 of the 65 patients (51%) randomized to carfilzomib, compared with 5 of 30 patients (17%) assigned to bortezomib.

Study details: The ongoing PROTECT trial enrolled 95 patients with relapsed multiple myeloma and randomized them to receive carfilzomib or bortezomib.

Disclosures: The PROTECT study is sponsored by Millennium Pharmaceuticals. Dr. Cornell reported having no financial disclosures.