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Intensive BP Control & Risk of Probable Dementia

JAMA; 2019 Jan 28; SPRINT Mind Investigators

Among adults with hypertension, intensive blood pressure (BP) control did not significantly reduced the risk of probable dementia, a new study concluded. Researchers studied the effect of intensive vs standard BP control on probable dementia from a randomized clinical trial conducted at 102 sites in the US and Puerto Rico among adults aged ≥50 years with hypertension but without diabetes or history of stroke. Participants were randomized to a systolic BP goal of either <120 mm Hg (intensive treatment group; n=4,678) or <140 mm Hg (standard treatment group; n=4,638). The primary cognitive outcome was occurrence of adjudicated probable dementia. Among the details:

  • Among 9,361 randomized participants (mean age 67.9 years, 35.6% women), 8,563 (91.5%) completed at least 1 follow-up cognitive assessment.
  • Median intervention period was 3.34 years.
  • During a total median follow-up of 5.11 years, adjudicated probable dementia occurred in 149 participants in the intensive treatment groups vs 176 in the standard treatment group (7.2 vs 8.6 cases per 1,000 person-years).
  • Intensive BP control significantly reduced the risk of mild cognitive impairment and the combined rate of mild cognitive impairment or probable dementia.


The SPRINT MIND Investigators for the SPRINT Research Group. Effect of intensive vs standard blood pressure control on probable dementia: A randomized clinical trial. JAMA. 2019;321(6):553–561. doi:10.1001/jama.2018.21442.