Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

DAPA-CKD: SGLT2 inhibitor benefit extends to chronic kidney disease without diabetes

Key clinical point: Dapagliflozin helps patients with albuminuria and declining eGFR levels whether or not they have type 2 diabetes.

Major finding: Dapagliflozin cut the incidence of substantially worsened chronic kidney disease by an average of 39% compared with placebo when added to standard treatment, with a number needed to treat of 19 to prevent one primary outcome event.

Study details: DAPA-CKD randomized 4,304 patients with chronic kidney disease to receive dapagliflozin or placebo over a mean of 24 years.

Disclosures: Dr. Heerspink has been a consultant to and received research funding from AstraZeneca and from several other companies.