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Cardiorespiratory Fitness & All-Cancer Mortality

Mayo Clin Proc; ePub 2018 Mar 27; Wang, et al

Nonexercise estimated cardiorespiratory fitness (eCRF) was inversely associated with all-cancer mortality in certain quintiles in women, a recent study found. A total of 8,506 participants from the Third National Health and Nutrition Examination Survey were included and were followed for all-cancer mortality. Participants’ CRF was estimated from nonexercised models that were determined by age, body mass index (BMI), waist circumference, resting heart rate, physical activity status, and smoking status, and further grouped into quintiles. Researchers found:

  • During a mean follow-up of 19.5 years, 455 cancer deaths (263 men and 192 women) were reported.
  • After adjustment, each 1-metabolic equivalent increase in eCRF was associated with 30% and 27% risk reduction for all-cancer mortality in men and women, respectively.
  • When eCRF was categorized into quintiles, hazard ratios (HRs) were 0.47, 0.81, 0.49, and 0.57 across incremental quintiles in women.
  • None of the HRs reached statistical significance in men.

Citation:

Wang Y, Chen S, Zhang J, et al. Nonexercise estimated cardiorespiratory fitness and all-cancer mortality: The NHANES III Study. [Published online ahead of print March 27, 2018]. Mayo Clin Proc. doi:10.1016/j.mayocp.2018.01.004.