Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Aspirin for Prevention of CV Events

JAMA; 2019 Jan 22; Zheng, Roddick

The use of aspirin in individuals without cardiovascular disease (CVD) was associated with a lower risk of CV events and an increased risk of major bleeding, a new study found. The systematic review and meta-analysis of included 13 trials with 164,225 participants without CVD (median age 62 years, 19% had diabetes). Researchers assessed the association of aspirin use for primary prevention with CV events and bleeding. The primary CV outcome was a composite of CV mortality, nonfatal myocardial infarction, and nonfatal stroke. The primary bleeding outcome was any major bleeding. Among the findings:

  • Participant median baseline risk of the primary CV outcome was 9.2%.
  • Aspirin use was associated with significant reductions in the composite CV outcome compared with no aspirin.
  • Aspirin use was also associated with an increased risk of major bleeding events compared with no aspirin.

Citation:

Zheng SL, Roddick AJ. Association of aspirin use for primary prevention with cardiovascular events and bleeding events: A systematic review and meta-analysis. JAMA. 2019;321(3):277–287. doi:10.1001/jama.2018.20578.

This Week's Must Reads

Combination model predicts imminent preeclampsia, Ciobanu A et al. Am J Obstet Gynecol. 2019 Feb 7. doi. org/10.1016/j.ajog.2019.01.235

Delayed cord clamping didn’t drop maternal hemoglobin in term cesarean deliveries, Purisch S. et al. Am J Obstet Gynecol. 2019 Jan;220(1):S37-38, Abstract 47

Dental device borrowed from sports world no help in pushing, Bergh E et al. Am J Obstet Gynecol. 2019 Jan;220(1):S39, Abstract 49

Enterovirus in at-risk children associated with later celiac disease, Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

Must Reads in Cardiology

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Aspirin for Prevention of CV Events, JAMA; 2019 Jan 22; Zheng, Roddick