Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

NSAIDs a Significant Mediator of CVD Risk in Osteoarthritis

Key clinical point: Increased risk of cardiovascular disease in osteoarthritis may be partly accounted for by NSAID use.

Major finding: NSAIDs mediate 41% of the total effect of osteoarthritis on cardiovascular disease risk.

Study details: Population-based cohort study in 7,743 individuals with osteoarthritis and 23,229 age- and sex-matched controls without osteoarthritis.

Disclosures: There was no outside funding for the study, and the authors had no conflicts of interest to declare.


Atiquzzaman M et al. Arthritis Rheumatol. 2019 Aug 6. doi: 10.1002/art.41027