Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Split-dose oxycodone protocol reduces opioid use after cesarean

Key clinical point: Split-dose regimen for oral oxycodone after cesarean delivery can reduce opioid side effects such as nausea and vomiting.

Major finding: A split-dose approach to oxycodone dispensing after cesarean section reduced opioid use by 56%.

Study details: Retrospective study of medical records of 1,050 women undergoing cesarean delivery.

Disclosures: The study was supported by the department of anesthesiology, perioperative, and pain medicine at Stanford (Calif.) University. One author declared travel funding from a university. No other conflicts of interest were declared.


Nanji J et al. Obstet Gynecol. 2019. doi: 10.1097/AOG.0000000000003305.